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Nutrition that Reduces Hot Flashes (2023 study)

By Lauren Plunkett posted 03-10-2024 17:38


Dietary advanced glycation end-products and postmenopausal hot flashes: A post-hoc analysis of a 12-week randomized clinical trial (March 24, 2023) - click for the full study

The participants in this study are postmenopausal women aged 40-65 and although living with diabetes was not a requirement of the study, the intervention is promising in reducing hot flashes while supportive of preventive health for women living with diabetes and/or insulin resistance.  


Dietary advanced glycation end-products (AGEs) may act as endocrine disruptors, this study examined the potential association of modifications to the intake of dietary AGEs with the frequency and severity of postmenopausal hot flashes.

Highlights from the article: 

  • Postmenopausal hot flashes are associated with an increased risk of cardiovascular disease and diabetes. 

  • AGEs are continuously generated during metabolism, and enhanced during hyperglycemia and/or conditions characterized by increased oxidative stress.

  • Excessive intake of dietary AGEs, has been linked to oxidative stress and inflammation, reduced innate immune defenses, and insulin resistance.

  • Cooking with high heat under dry conditions, as in grilling, leads to significant formation of AGEs, especially in animal-derived foods, which are also rich in fats.

  • In a recent 12-week randomized clinical trial, a low-fat plant-based diet greatly reduced vasomotor symptoms in postmenopausal women. 

  • 71 participants that completed the study were randomly assigned to 2 study groups.

    • Dietary AGEs decreased 73% in the intervention group.

    • About 44% of the reduction of the dietary AGEs in the intervention group was due to the reduction of meat intake, and 24% due to decreased dairy intake. 


The reduction in dietary AGEs with a low-fat plant-based diet was associated with a significant reduction in the frequency of severe and moderate-to-severe postmenopausal hot flashes, independent of changes in energy intake and weight loss.

“Since circulating AGEs are a modifiable risk factor for type 2 diabetes, and cardiovascular disease and reducing dietary AGEs is effective in reducing the circulating levels of AGEs and improving markers of cardiometabolic health, it is crucial to identify effective strategies that will improve cardiometabolic health, particularly in postmenopausal women with hot flashes, who are at an increased risk of developing diabetes and cardiovascular disease.”





03-18-2024 09:45


Thank you for sharing this awesome article! I am always looking for new ways to promote the benefits of plant-based nutrition. This is a great example of empowering women to make positive lifestyle changes to improve their health and reduce their healthcare costs

Warmest regards,


03-12-2024 07:36

AGEs! I didn't make the connection.

For this n=1, I can say that my plant-based diet has helped lead me through a practically symptom-free bout with menopause. My mom had a horrible time, so genetics can't take credit here. 

This is proof positive that we should recommend a plant-based diet to our patients who struggle with hot flashes and other menopause symptoms.