Tirzepatide: worth the weight Prepared by: Ana Safri, PharmD PGY2 Ambulatory Care Resident, Boston Medical Center Reviewed by: Katelyn O'Brien, PharmD, BCPS, CDCES, BC-ADM and Courtney Cameron, PharmD
What is tirzepatide?
Tirzepatide (Mounjaro) is the first in its class peptide that activates both glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors. Both GIP and GLP-1 are incretin hormones released in response to nutrient uptake in the gut, however GIP is responsible for ~2/3 of the total effect, allowing a synergistic effect with tirzepatide’s mechanism. Similar to other GLP-1, GIP stimulates insulin ...